The 10 kV Isolation Amplifier is a high-safety analog signal isolation device designed for nuclear fusion plasma experiments and high-voltage, high-electromagnetic-interference environments. The unit provides electrical isolation withstanding up to 10 kV DC, enabling safe and stable signal transmission under high common-mode voltage conditions. The system employs a custom-designed isolation transformer combined with a multi-stage analog signal processing architecture, achieving exceptional isolation performance without compromising signal accuracy or stability. Housed in a compact chassis with standardized connectors, the instrument is well suited for plasma diagnostics, high-voltage power supply testing, and high-energy physics measurement systems.